To help keep your Mac OSX desktop tidy, you may want to move your screenshots to a custom folder.
Create a folder called Screenshots (or any name you like) in your desired location. For this article I am going to create Screenshots folder on the Desktop.
Fire up a Terminal window and enter the following command:
defaults write com.apple.screencapture location /Users/<username>/Desktop/Screenshots
You will then need to restart SystemUIServer to make the system aware of the change you just made.
Done! Next time you take a screenshot, your desktop will still be clutter free and all your screenshots will be placed in the Screenshots folder.